EFFECT OF TACROLIMUS ON SOME IMMUNE SYSTEM INDICATORS IN MEN AND WOMEN AFTER KIDNEY TRANSPLANTATION

Objective. To study the effect of tacrolimus on some cellular parameters of the immune system in patients 1, 3 and 5 years after kidney transplantation.

Materials and methods. The method of flow cytometry examined 63 people of the second period of adulthood with a transplanted kidney with terms after surgery of more than 1 year, more than 3 years and more than 5 years. The control group consisted of 15 men and 15 women of the same age. Statistical data analysis was performed using the R version 4.0.5 application package (2021-03-31).

Results. The study revealed a decrease in the number of DC2 1 year after surgery in men, both in comparison with women of the same group and in comparison with the control group, while at a later date, gender differences are leveled, and the number of DC2 remains reduced in comparison with control group. Analysis of the DC2/DC1 ratio revealed its decrease in comparison with healthy people in all periods of the study. At the same time, 5 years after the operation, a lower DC2/DC1 ratio was found in men compared to women in the same group. Also at all times after kidney transplantation, there is a statistically significant increase in the percentage of total T-lymphocytes and a decrease in NK cells and pre-B and B-lymphocytes.

Conclusions. The found gender differences in the content of dendritic cells and their ratio may indicate the possibility of an increased intensity of antigen presentation in men compared to women. The revealed increase in the content of T-lymphocytes may be a compensatory response to a decrease in NK cells and pre-B and B-lymphocytes, or an insufficient dosage of tacrolimus.

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Автор(ы): A. T. Shchastny, A. S. Osochuk, A. F. Marcinkevich, S. S. Osochuk