Objective.To evaluate the relationship between bone mineral density and risk factors for osteoporosis and fractures in patients with CKD and SHPT.
Material and methods. Risk factors for decreased of bone mineral density and fractures, as well as parameters of bone mineral density assessed by double x-ray absorptiometry, were analyzed in 452 patients with various stages of CKD and 50 persons in the comparison group.
Results. Fracture incidence was 12.2% in all persons with CKD and increases to 14-18% in dialysis and transplanted patients. It has been shown that, along with the level of PTH, the presence of SHPT, risk factors for a decrease in BMD are a number of generally recognized risk factors for a decrease in BMD, as well as risk factors associated with CKD: the level of GFR and the stage of CKD, the duration of dialysis, the presence of anemia, the level of prolactin and the presence of hyperprolactinemia.
Conclusion.The data obtained are the basis for the development of recommendations for the diagnosis of osteopathy in SHPT and CKD, as well as multifactorial prevention and correction of this pathology.Ключевые слова:
Автор(ы): N. V. Karlovich, T. V. Mokhort