Objective. The aim of the study was to determine the role of cholesterol, the sex hormones precursor, in gestation trimesters I and II for subsequent development of treatment for preventing miscarriage.

Materials and methods. 31 pregnant women with spontaneous and induced abortions in pregnancy trimesters I and II and 34 pregnant women with physiological pregnancy were examined. Cholesterol, triglycerides, low and high density lipoproteins were determined by colorimetric method.

Results. The concentrations of the studied compounds did not change significantly during the physiological pregnancy trimester I. The embryo death and the fetal egg residues removal from the uterus also did not affect the studied parameters blood contents. In the pregnancy trimester II, the levels of the studied compounds were significantly higher than in trimester I, and the pregnancy termination led to a statistically significant decrease in the blood serum contents of cholesterol and low-density lipoproteins.

Conclusion. The specific features of the cholesterol metabolism are important for gestation in trimester II. By this period, its concentration increases significantly as compared with that in trimester I, and an artificial interruption of the gestation in this period affects evidently the blood serum contents of cholesterol and low-density lipoproteins. In the gestation trimester I, pregnancy termination does not affect the performance of cholesterol metabolism probably due to its physiological excess. Since this compound is a precursor of sex hormones including progesterone, it can be assumed that the starting material for the endogenous synthesis of progesterone in the gestation trimester I is sufficient. Therefore, the pregnancy maintenance by prescribing hormonal drugs in trimester I needs additional justification. In trimester II, under the termination of pregnancy threat it is advisable to correct the cholesterol metabolism as its stock can deplete.

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Автор(ы): S. L. Voskresensky, V. L. Trishina