CONTENT OF PROGESTERONE PRECURSOR IN BLOOD SERUM OF PREGNANT WOMEN WITH THREATENED MISCARRIAGE IN FIRST TRIMESTER OF GESTATION

Objective. To determine the severity of the effect of hormonal and non-hormonal therapy of the miscarriage threat on the progesterone cholesterol, low and high density lipoproteins, triglycerides levels in the first trimester of gestation.

Materials and methods. 110 women were examined in the first trimester of gestation and divided into 3 groups. The first group included 35 pregnant women with the threat of miscarriage who received the non-hormonal therapy included sedatives of plant origin, antispasmodics, vitamins, therapeutic and protective regimen. The second group consisted of 40 pregnant women with threat of miscarriage who received dydrogesterone along with the above mentioned therapy. The third group consisted of 35 pregnant women who received micronized progesterone instead of dydrogesterone. Cholesterol, low and high density lipoproteins, triglycerides were determined by the colorimetric method.

Results. The concentrations of the studied compounds (cholesterol, low- and high-density lipoproteins, triglycerides) did not change statistically significantly in case of administration of both hormonal and non-hormonal therapy during the first trimester. Dydrogesterone or micronized progesterone administration in case of threatened miscarriage did not affect the metabolism of cholesterol as the precursor of progesterone significantly.

Conclusion. In case of clinical signs of the termination of pregnancy threat in the first trimester a woman’s body has enough biochemical reserve for producing endogenous progesterone.

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Автор(ы): S. L. Voskresensky, V. L. Trishina