The article discusses the state of the scientific and the practical physiotherapy, analyzes the negative trends in its development in addition to the successes achieved. An attempt has been made to identify the directions the physical therapy will develop during the next 20 to 25 years. Such methods as simultaneous, transcranial, biosynchronized, and biocontrolled physiotherapy searching and developing importance for medicine is substantiated. The study of problems in the physiotherapy optimization and personification as well as its use integrated with other therapeutic options still remains relevant. Possibilities of using therapeutic physical factors in personalized, translational, preventive, and precision medicine are determined. The article emphasizes that both experimental studies and clinical observations should be conducted in accordance with the principles of evidence.