Objective. To study the retinoblastoma prevalence in the Republic of Belarus for 1997—2018.
Materials and methods. The data of Pediatric Cancer Subregistry, the case records of 144 patients treated and surveilled at the Center for Pediatric Oncology, Hematology and Immunology in 1997—2018 was analyzed.
Results. Retinoblastoma was detected in 144 children including 73 (50.7%) boys and 71 (49.3%) girls. The retinoblastoma crude incidence in the age group of 0—14 years for the period 1997—2018 was 0.406±0.034. The standardized incidence in the age group of 0—14 years for the period 1997—2018 was 0.497±0.041. The disease was diagnosed in 38.2% of cases on the first year of life. The monolateral retinoblastoma was detected in 97 (67.4%) patients, the bilateral retinoblastoma — in 47 (32.6%) cases. The disease family histories were revealed in 4 (2.8%) children. 101 (52.9%) eyes were enucleated including the eyes in 24 children with the binocular retinoblastoma and 75 children with the monocular retinoblastoma. The overall survival rate for the study period was 91±2%. The relapse-free survival rate was 73±4%.
Conclusion. The age standardized retinoblastoma incidence in the Republic of Belarus had remained practically stable in 1997—2018 (the annual gain — 0.90%) though the crude disease incidence (the annual gain — 3.22%) increased being, evidently, caused by the population growth and heterogeneity.Ключевые слова:
Автор(ы): O. O. Makarevich, N. E. Konoplya, D. V. Kochubinskii, M. A. Gorbach, K. P. Zhyliayeva, V. S. Mlechko