Objective. To determine the prevalence of high oncogenic-risk human papillomavirus (HPV) in the prostate secretion (EPS) expressed from patients examined for genital organs inflammatory and associated diseases.

Materials and methods. Totally, 110 men with genital diseases and comorbidities were examined. The high-risk HPV DNA presence in the patients’ EPS was detected by PCR.

Results. High-risk HPV in EPS was detected in 32 (29.1%) of 110 men. Various diseases were diagnosed in 77 (70.0%) patients including chronic prostatitis, reactive arthritis, sterility. Of these, inflammatory diseases were diagnosed in 40 (51.9%) persons and non-inflammatory — in 37 (48.1%) patients. In cases of inflammatory diseases and sterility, HPV was detected reliably more frequently (60.0%) than in cases of non-inflammatory diseases (21.6%, p=0.0004).

Conclusion. The HPV infection prevalence in men with genital organs inflammatory diseases and sterility requires further studies and new conservative methods of treatment development.