Objective. To study the effectiveness of preoperative radiosurgery for patients with brain metastasis.

Materials and methods. Results of the combined stereotactic therapy consisting of preoperative radiosurgery on Gamma Knife and surgical resection of brain metastasis were analysed in 45 patients. Cumulative incidence of local recurrences and overall survival were studied. Comparison with control group which included 70 patients after surgical resection and whole brain radiation therapy was made.

Results. Median OS for the patients in the main group was 23, 2 months (in the control group median OS was
15,2 months; p=0,08). There was statistically significant decrease in cumulative incidence of the local recurrences after preoperative radiosurgery (p=0,01). No cases of radionecrosis was registered.

Conclusion. Preoperative radiosurgery for brain metastasis can provide statistically significant reduction in local recurrence rates without increased risk of complications.