THE ROLE OF CYTOKINES IN SARS-CoV-2 INFECTION AND WAYS TO BLOCK CYTOKINE STORM

The article, based on modern literature data, provides a comprehensive analysis of the problem of the role of cytokines in the new coronavirus SARS-CoV-2 (COVID-19) infection. Information on the immunopathogenesis of SARS-CoV-2 infection is presented. The fact is emphasized that the severe form of this disease is characterized by systemic hyperinflammation, acute respiratory distress syndrome, multiple organ failure, often leading to death. Provisionally called a cytokine storm caused by excessive immune responses, it is recognized as the leading cause of severe SARS-CoV-2 infection. With the accumulation of modern information on the immunopathogenesis of the new coronavirus SARS-CoV-2 (COVID-19) infection, several approaches are currently being used in real medical practice to treat the observed cytokine storm associated with COVID-19. New approaches to the treatment of SARS-CoV-2 (COVID-19) infection, aimed at blocking cytokines are of practical interest from the issue of clinical pharmacology. In particular, this is the use of IL-6 inhibitors (tocilizumab, sarilumab), IL-1 inhibitors (anakinra), and Janus kinase (JAK) inhibitors (baricitinib). In recent studies by various authors, the implementation of such approaches has shown promising potential for the treatment of severe forms of COVID-19. The information presented has great practical importance for practicing physicians.

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Автор(ы): I. V. Vasilevski