CHARACTERISTICS OF VARIOUS EXPERIMENTAL MODELS OF ADHESIVE DISEASE OF THE ABDOMINAL CAVITY

The development of abdominal surgery is inevitably accompanied by an avalanche-like increase in postoperative complications, among which the adhesive process of the abdominal cavity occupies the most important place. Experimental studies were carried out on 95 male guinea pigs. The study of the effectiveness of various models was carried out according to a number of factors: lethality (cl), the presence of intestinal obstruction (co) and complications of modeling ADAC (cc), the number (cn), prevalence (cm) and type of adhesions (cv), as well as the time factor (ct) spent on modeling.

As a result of the study, it was revealed that an isolated modeling effect has little impact on the occurrence of adhesive disease of the abdominal cavity. The adhesive process is the result of a long-term exposure of a complex of factors: chemical (denaturation (r=-0.4, p<0.01); alkalosis (r=0.38, p<0.01)), biological (inflammation (r=0.01) .44, p<0.01)), physical (heating during polymerization (r=0.6, p<0.01); abrasive effect (r=0.35, p<0.01)), intra-abdominal hypertension, hypoxia of the peritoneal tissues. At the same time, the impact of any of the modeling factors on average causes a decrease in the partial pressure of oxygen by 45 % (28.7 mm Hg in the control group, 15.5 mm Hg in the experimental groups, p=0.0007). Isolated damage to the mesothelium by a chemical or physical factor is not enough to cause an adhesive process in the abdominal cavity.

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Автор(ы): D. A. Kluiko, S. A. Zidkov