SYSTEM ANALYSIS OF THE ELECTRICAL AND CELLULAR-MOLECULAR FOUNDATION OF THE HEART WORK AND SOME OF ITS DISORDERS. II. ELECTRICAL AND CELLULAR-MOLECULAR ASPECTS OF THE CONDUCTION OF PACEMAKER POTENTIALS, EXCITATION AND MYOCARDIUM CONTRACTION

The article the differences in the mechanisms of contraction initiation of the skeletal muscles and myocardium are denvisaged. The mechanisms of conduction of pacemaker potentials by conduction system of the heart, the role of gap junctions and ionic channels in conduction mechanisms are discussed. Modern data about the role of ionic channels and the dynamics of ion currents in the origin of various phases of the action potential of contractile cardiac myocytes, in the spread of excitation through the myocardium and the role of calcium in the excitation contraction coupling are outlined. The significance of refractoriness and its dynamics in the propagation of excitation and myocardium contraction are discussed. Examples of the relationship between impairments in the functioning of gap junction channels and ion channels with the development of cardiac arrhythmias and other cardiac diseases are given.

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Автор(ы): A. I. Kubarko