Objective. To establish the relationship between the incidence of fetal hydrops caused by parvovirus B19 and the epidemic stages of the infection.

Materials and methods. Diagnosis of parvovirus infection was based on the detection of specific IgM and DNA of parvovirus B19 in the blood serum of pregnant woman and a newborn or in the autopsy materials of the fetus.

Results. In 2012—2021 in Belarus one epidemic rise of parvovirus infection lasting two years (2015—2016) was registered. During the same ten-year period in total 18 cases of fetal hydrop caused by parvovirus B19 were confirmed, which were detected with the same frequency (from 1 to 3 cases per year), during both rise and fall of in the incidence of parvovirus infection in the country. Parvovirus infection was revealed in 23.7 % of cases of non-immune fetal hydrops, the incidence of its was 1.7 per 100,000 newborns, that similar to indicators in the developed countries.

Conclusions. The data obtained indicate a high level of detection and diagnosis of non-immune fetal hydrops caused by parvovirus B19 in Belarus. From 1 to 3 cases were confirmed annually and its incidence was not related to the epidemic stage of the infection. Therefore, the examination of non-immune fetal hydrops on parvovirus B19 etiology should be carried out regardless of the current incidence rate of parvovirus infection in the country.