HOW IMMUNE SYSTEM WORKS. PART 2. THE ROLE OF T AND B LYMPHOCYTES

The article presents data on modern view on the T and B cells defining the acquired immunity biology and physiology. The antigen (Ag)-dependent and Ag-independent stages of the T and B cell differentiation are described. A detailed description of the cell activation and of the Ag-specific cell receptors, costimulatory molecules, cytokines participation in the T or B cell response to Ag enhancement is made. Modern data have been collected to determine the T or B cells subpopulations diversity based on phenotyping or functional assessment of producing cytokines. The value of the T or B cell diversity in the norm or in pathological states (including diseases) is demonstrated. It has been concluded that both T and B cells are able to сarry out both the Ag-specific and Ag-nonspecific immune functions.

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Автор(ы): M. P. Potapnev