REACTIVE OXYGEN SPECIES, THEIR FORMATION AND ROLE IN THE BODY

The terminology, chemical origin and properties of radical and nonradical representatives of reactive oxygen (ROS) and nitrogen species are stated. The concepts of oxidative and reductive stress, exogenous and endogenous sources of ROS are discussed. The molecular mechanisms of lipids, proteins, and nucleic acids modification by ROS as the basis for oxidative damage to cellular structures and the whole organism as well as changes in the gene expression under conditions of oxidative stress are considered. Enzymatic and non-enzymatic defense mechanisms against oxidative stress are discussed in detail.

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Автор(ы): A. D. Tahanovich