The treatment of patients with non-small cells lung cancer (NSCLC) have been changed beginning from full refuse in medical aid and palliative treatment to till high tech over radical surgical operations for the last ten years. Our research goal consisted into analysis of treatment the patients with NSCLC depending on the base factors of prognosis. Studying group consisted from 790 patients with NSCLC received treatment in Minsk Oncological Department from 2001 till 2018 years. Monovariant and multivariant analysis determined influence such indexes like gender, TNM, disease state and massive lesions of mediastinal lymph nodes. On the background of this analysis group of patients with poor prognosis have been determined. These group of patients consisted from men with NSCLC more than 65 years old and with N3 corresponding to TNM descriptor.