In the article we review published data on increased levels of blood cardiac troponins in the blood due to different clinical reasons as well as on false positive results of the cardiac troponins tests.

We introduce a methodological approach which includes simultaneous measurements of blood cardiac troponins levels and activity of creatine kinase MB considering the data of clinical and instrumental diagnostic investigations. The approach enables a definite distinction between true elevated troponin I levels and false positive results.

We propose a novel procedure to exclude false positive results of troponin I tests using measurements in serial linear dilutions of blood serum.

We present a clinical case to demonstrate the necessity of differentiated interpretation of increased blood cardiac troponins levels in patients with COVID-19.