Despite the general decrease in mortality among patients with tuberculosis (TB), in the course of the TB inpatient treatment, critical conditions requiring hospitalization to the intensive care unit (ICU) develop in 9.2% of cases and TB patients can die in some cases. The study was aimed at identifying risk factors for death at the ICU and correcting the therapy for the underlying and concomitant diseases. Risk factors for death were studied retrospectively in 230 TB patients admitted to the ICU in 2016-2019 due to the development of critical states. In the studied cohort of patients hospitalized and died at the ICU, the statistically significant factors influencing the mortality rate were the following: the TB process extrapulmonary or pulmonary localization other organs and systems damaged; presence of destructive forms of tuberculosis (fibrous-cavernous tuberculosis); presence of meningitis / encephalitis; presence of rifampicin-resistant tuberculosis and, in particular, extensively drug-resistant tuberculosis; HIV infection with a CD4 cell count below 200; application of the traditional (“old”) treatment regimen; history of diabetes mellitus.