An overview of the clinical application of the method for the hemodynamic phenotype determining by regression modeling of blood pressure parameters is presented in order to demonstrate the capabilities of this method in functional diagnostics of blood circulation. This approach allows detect latent circulatory disorders in normotensive people — dysfunctional hemodynamic phenotypes including hypertensive ones and pathological classes of the harmonic phenotype. Those patients need additional examinations, health dynamic monitoring and medical prophylaxis. The hemodynamic phenotype should be considered when prescribing treatment for hypertensive patients and for persons with obstructive sleep apnea (OSA). The dysfunctional diastolic phenotype is characterized by a low probability of the target blood pressure achieving regardless of the drugs administration and their quantity and by a lower quality of life especially the drug treatment intensified. The patients with such phenotype should be treated comprehensively using non-pharmacological methods of influencing on the health physical and psycho-emotional components being mandatory. The hemodynamic phenotype allows select patients with OSA for the CPAP-therapy. The determination of the phenotype on blood pressure parameters as proposed does not require special equipment and is available in any level of medical care.