Cervical cancer remains one of the most prevalent malignancies and one of the leading causes of cancer mortality worldwide. Effective cervical cancer screening system is known to be a crucial factor of the cervical cancer prevention. It allows diagnose the precancerous cervical lesions at the curable stage with good prognosis. Effective extension of cervical screening program is HPV-related tissue biomarkers identification their assessment being a helpful tool for determination of the further treatment strategy and outcome prediction.