ANTIBIOTIC RESISTANCE OF ESCHERICHIA COLI SEPARATED FROM WOMEN HAVING URINARY TRACTS INFECTIONS AND FROM PREGNANT WOMEN

Objective. To determine the antibiotic resistance (including the multidrug resistance) of uropathogenic Escherichia coli and the antibiotics minimum inhibitory concentrations (MICs) for different types of urinary tract infections.

Materials and methods. The susceptibility to 19 antimicrobial drugs of 192 urinary isolates of E. coli to 19 antimicrobial drugs was determined according to CLSI and EUCAST methods. MIC determination was performed with agar dilution method.

Results. Uropathogenic E. coli are characterized by high resistance to penicillins and the 1st generation cephalosporins (60.4—94.3%), tetracycline (73.5%), chloramphenicol (62.0%), nalidixic acid (55.8%), tigecycline (55.7% of insusceptible strains). 34.9—47.4% of isolates were insusceptible to fluoroquinolones. Less than 20% of isolates were resistant to cephalosporins of the 3–4th generations and aztreonams. Carbapenems and nitrofurantoin were most effective. Over 76% of isolates were resistant to three or more antibiotics at the same time. In chronic urinary tract infections, the proportion of resistant strains to aztreonam, fluoroquinolones of the 2d and 3rd generations, fosfomycin, ciprofloxacin isolates was higher.

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Автор(ы): I. A. Gavrilova, S. V. Busik, V. V. Slizen