Objective. To study the effect of extracorporeal hemoadsorption using hemoadsorbent «LPS-hemo» on plasma amino acid concentrations in patients with sepsis of various etiologies.
Materials and methods. 22 patients diagnosed with sepsis of various etiologies were examined. The diagnosis was made on the basis of SCCM/ESICM criteria and laboratory data (level of C-reactive protein, presepsin, procalcitonin). Patients with chronic diseases leading to impaired amino acid metabolism were excluded. The patients were divided into two groups: the control group (n=13), where used standard treatment without extracorporeal detoxification methods, and the experimental group (n=9), where hemoadsorption was carried out using “LPS-hemo” hemoadsorbent. In the control group, plasma amino acid levels were determined by high performance liquid chromatography twice, one hour apart. In the experimental group — before hemoadsorption and immediately after. There was no additional nutritional support applied between two measurements in both groups. The Wilcoxon test was used for statistical analysis of the data.
Results. In the control group, there was no statistically significant decrease in the level of amino acids between the two measurements (in all cases, p>0,05). In the experimental group, after hemoadsorption, a decrease in plasma concentration of glutamine by 28 %, histidine by 2%, 1-methylhistidine by 12 % and lysine by 28 % was found (in all cases, p<0,05).
Conclusion. Extracorporeal hemoadsorption using hemoadsorbent “LPS-hemo” helps to reduce the concentration of
a number of amino acids in the plasma in patients with sepsis. It is recommended to prescribe additional nutritional support.
Автор(ы): N. V. Belyavsky, R. E. Yakubtsevich, A. A. Glazev, S. D. Klisa, A. V. Maksimenko, E. V. Boltrukevich