The scientific literature describes in detail approaches to the diagnosis, treatment and prevention of peritoneal adhesions. However, the causes of this disease and its pathogenesis are not sufficiently covered. The aim of the study was to research the parameters of tissue respiration in the visceral peritoneum in experimental peritoneal adhesions. As a result of a study on 95 laboratory animals, it was revealed that any of the models causes hypoxic changes in the peritoneum to a greater or lesser degree — a decrease in oxygen partial pressure by 45% (in the control group 28.7 mm Hg, in the experimental groups — in average of 15.5 mm Hg; p=0.0007). The maximum manifestation of hypoxia was revealed in the group with modeling of the adhesive process with the use of propanol — 4.65 mm Hg, the minimum — in the group with the use of acetone 23.3 mm Hg. In the group with the usage of a two-stage model with the use of talc and subsequent adhesiolysis the partial pressure decreased by 63% compared with the control group and amounted to 10.5 mm Hg.