Objective. To study effectiveness of inhaled antibacterial drugs in the treatment of severe pneumoniae.

Materials and methods. A comprehensive examination and treatment of 24 patients with severe bilateral polysegmental pneumonia was performed. The patient’s mean age was 55.7±14.5 years. The offered method of inhalation antibiotics administration to a patient breathing spontaneously through a tracheostomy or an endotracheal tube was based on introducing the antibiotic into the tracheostomy or the endotracheal tube into carina area of the trachea through an aspiration catheter.

Results. The method was used as a supplement to the complex intensive therapy of patients receiving intravenous antibacterial drugs. After P. aeruginosa isolation, colistate was added to the basic regime by 2 mln ME 3 times a day inhaled through the tracheostomy tube according to proposed method of the inhalation antibiotics administration within the antibacterial therapy main scheme. The temperature dynamics, laboratory data, X-ray picture and microbiological analysis were evaluated as a marker of the applied method efficiency. A positive X-ray dynamics, the temperature (p=0.019) and ESR (p=0.011) values decrease, normalized leukocyte counts (p=0.035) and the microbiological sputum examination negative results while ESR and leukocyte formula not diffing significantly ring (p<0.05) were observed in 6 days.

Conclusion. The first experience of administrating inhalation antibiotics showed their rather high efficiency in the severe pneumoniae treatment.