Chronic scrotal pain syndrome (CSPS) is observed, patients co-present in approximately 4.5 % of all urological care seekers. The etiology and pathogenesis of diseases are completely unclear, therefore, there are no recommendations for diagnosis and expediency. The accumulated data on its diagnosis and especially depending on the identified cause, including surgical, are presented, and the treatment of idiopathic CPMS with the involvement of non-steroidal anti-inflammatory drugs and antidepressants is also discussed. The presence of a complex of measures with the participation of psychiatrists, if necessary, is emphasized.