In recent scientific studies abdominal compartment syndrome and intra-abdominal hypertension are increasingly recognized as etiological causes of multiple organ failure and mortality in surgical patients. The objective of the study was researching of the relationship between intra-abdominal hypertension, hypoxia of peritoneal tissues and the expression of a hypoxia-induced factor as one of the links in the formation of abdominal adhesions. The experimental study was carried out on 25 guinea pigs, which had a total of 73 measurements performed by direct oximetry, and an immunohistochemical analysis of the expression of the hypoxia-induced factor was carried out. As a result of the study, it was proved that in conditions of simulated intra-abdominal hypertension, there is an increase in the expression of the hypoxia-induced factor (HIF-1a) by 3 times (by 297.6%), as a consequence of tissue hypoxia and a decrease in oxygen partial pressure by 91% (p<0.0001). Intra-abdominal hypertension, compression of abdominal vessels and inhibition of the activity of oxygen-utilizing structures in the early postoperative period are prognostically unfavorable factors in the formation of the adhesive process of the abdominal cavity.