MAST CELL ACTIVATION SYNDROME: POSSIBILITIES FOR PHARMACOTHERAPY

About a century and a half has passed since Paul Ehrlich first described mast cells, but even today, in-depth study of the functions of mast cells continues, detailing their participation both in maintaining health and elucidating their role in various pathological conditions. Modern advances in mast cell research have strengthened the understanding that mast cells have unique immune functions, a better understanding of which will have a major impact on human health. There is increasing evidence of their participation in the pathogenesis of not only allergic, but also other diseases, including SARS-CoV-2 infection, psoriasis, myalgic encephalomyelitis, multiple sclerosis, diseases of the digestive system, rheumatoid arthritis, interstitial cystitis, tumor development, cardiovascular vascular diseases and other pathologies associated with chronic inflammation. Modern data on the function of mast cells, their primary and secondary dysfunction, including mast cell activation syndrome, require a new analytical approach — a new worldview. The potential of mast cells and their numerous mediators as therapeutic targets and biomarkers of disease severity and treatment outcome has been actively discussed in the recent literature, which is consistent with the principles of precision medicine.

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Автор(ы): I. V. Vasilevsky