The effects of treating patients with liver echinococcosis with medical ozone and the method clinical and experimental development and implementation for managing residual liver cavities after echinococcectomy were analyzed.One of the characteristic complications of the surgical treatment for large echinococcal cysts is short-term bile outflowing from the residual cavity in most cases including in absence of obvious cystobiliary fistulas in the residual cavity intraoperative revision. In some cases, the formed cystobiliary fistulas have a long course.The full washing of the residual cavity with antiseptic solutions possible via the drainage as well as introduction of the method based on the medical ozone use for its sanation developed by us provides prevention of developing echinococcectomy purulent complications.