Toxic epidermal necrolysis (Lyell’s TEN; Stevens — Johnson syndrome) is an urgent problem of modern medicine due to the high mortality, poor research data, lack of criterial etiological signs and consensus based methods of the patient management. The disease occurs rarely: no more than 6 cases / million person-years for all races, ages and genders. The paper presents current cumulative data on the TEN etiology, pathogenesis. The clinical experience of managing a child with TEN is presented the clinical manifestations and visual dynamics of the dermatological damage resolution registered in detail. Laboratory monitoring of the patient management in the intensive care unit (ICU) is demonstrated. The patient inter-discipline management the outcome being positive is described. The specific features of the patient managing as well as of the methods of examination and therapy applied may be useful for anesthesiologists, intensivists, surgeons, dermatologists, infectiologists.