Despite the rapid development of modern surgery, the problem of prevention and treatment of adhesions of the abdominal cavity and its complications remains extremely urgent. The experiment was carried out to determine the effect of the presence of fibrin in the abdominal cavity on the expression of the factor induced by hypoxia. As a result of the study, it was proved that the use of streptokinase does not cause bleeding in laboratory animals after modeling the adhesive process. The use of drugs that cause fibrin degradation without increasing the likelihood of internal bleeding is a priority in the treatment of adhesions of the abdominal cavity.