Objective. To determine the diagnostic informational value of indicators characterizing the inflammatory process activity in the benign prostatic hyperplasia (BPH) patients.
Materials and methods. The blood serum and urine cytokines, the blood serum C-reactive protein (CRP), zinc, and antioxidant activity were determined in 132 BPH patients and in 54 healthy men (control) aged 45-60 years.
Results. The serum cytokines considered the key inflammation mediators in BPH persons increased significantly in comparison with those in the control group (p<0.05). The statistical significance of the IL-6 and IL-8 correlation dependence in comparison with the control group positively noticeable (r = 0.57) and of the TNF a with the blood serum IL-8 highly positively noticeable (r = 0.71) provides the association between the prostate chronic inflammation and the BPH progression. No statistically significant difference in the urine cytokine levels in the BPH patients and in the control group (p>0.05) was revealed. The level of CRP levels and the blood serum antioxidant activity were non-specific and less informative for predicting of the BPH progression. The blood serum zinc considered to be important in the cytokine production regulation was low statistically. The zinc deficiency was revealed in 38.7% of the patients examined.
Conclusion. Cytokines, IL-8 in particular, can be used as additional prognostic biomarkers of the activity of prostate hyperplastic processes.Ключевые слова:
Автор(ы): D. М. Nitkin, N. А. Gres, P. V. Milasheuski, Т. М. Yuraha, P. Т. Zhurko