Objective. To evaluate the dose distribution parameters and beam-on time of the 3D-conformal radiotherapy (3D-CRT), intensity-modulated radiotherapy (IMRT), volumetric modulated arc therapy (VMAT), and flattening-filter free VMAT (FFF-VMAT) techniques using an active breathing control device in left-sided breast cancer radiotherapy.
Materials and methods. Eighty female patients after an adjuvant radiotherapy for left-sided breast cancer were enrolled in the study. 3D-CRT, IMRT, VMAT, and FFF-VMAT plans were generated for each patient. The dose distribution parameters and beam-on time for 320 plans were evaluated and compared.
Results. The FFF-VMAT technique usage reduced the beam-on time by 65.9% and 24.7% compared to the IMRT and VMAT durations, respectively, no significant dose distribution differences between the plans was found. The FFF-VMAT and 3D showed the clinically equivalent value of the beam-on time parameter. The study revealed 74.8%, 54.2% and 65.9% (р<0.001) beam-on time increase for the IMRT technique compared to the 3D-CRT, VMAT, and FFF-VMAT procedures, respectively.
Conclusion. Beam-on time should be taken into account for radiotherapy session time optimization and active breathing control treatment tolerance improvement.
Автор(ы): D. D. Mychko, O. R. Sinkevich, Yu. A. Zazybo, P. D. Demeshko