Health technology assessment (HTA) is an information management tool and therefore a tool for those who are responsible for policy and management. Depending on the purpose of the process of the assessment of medical technology, the level of provision and potential use of its results, it is proposed to distinguish two blocks in the general pool of trials related to HTA in the Republic of Belarus: scientific HTA and expert HTA (clinical and economic expertise). The goals and objectives of HTA in the health care system have been determined. The principles of the functioning of the HTA department as a structural subdivision of a scientific medical organization for the practical implementation of researches and expertise in the field of HTA are formulated.